Months after the events of "Amazing Spider-Man", Peter Parker seems to be getting used to his new role as the city's main protector. Saving kittens from tress. Stopping a bunch of bullies from picking on a kid, while saving the city from criminals on a daily basis. However, he still struggles with his love for Gwen Stacy, and his promise that he made with her dying father that he'd stay away from her. Meanwhile, a slew of villains from Oscorp look to make Peter's life a living hell.

Thor returns to Asgard, as he tries to restore order within the nine realms. His brother is locked away in prison for his crimes against humanity and the Asgardians. Meanwhile, a dark force emerges that forces Thor to forge an alliance with his brother, Loki, to combat a threat that could potentially destroy the balance of the universe as we may know it.

In this modern retelling of the wall crawler's origins, it explores even deeper into Peter Parker's past like never before. Upon his investigation into his parents' mysterious disappearance, Spider-Man soon finds himself crossing paths with the infamous Lizard.