Two mutant brothers, Logan and Victor, born 200 years ago, suffer childhood trauma and have only each other to depend on. Basically, they're fighters and killers, living from war to war through U.S. history. In modern times, a U.S. colonel, Stryker, recruits them and other mutants as commandos. Logan quits and becomes a logger, falling in love with a local teacher. When Logan refuses to rejoin Stryker's crew, the colonel sends the murderous Victor. Logan now wants revenge.

Four astronauts have their lives changed forever, when they end up being hit by a cloud of cosmic radiation. Reed Richards now has the ability to stretch his body like elastic. Sue Storm (Alba) is now the invisible woman. Johnny Storm becomes the human touch and Ben Grimm becomes the 'Thing', a man made out of rock. But there is one problem. The journey's sponsor, Victor von Doom has also been affects and with full power, is a dangerous force which needs to be stopped, before it's too late.

With Von Doom back in his homeland of Latveria the fantastic four have new troubles when Galactus has decided that Earth is his next target. When his henchman, The Silver Surfer, is sent to Earth he discovers that he's getting more than he bargained for when he encounters the Fantastic Four. But that's not all when Dr. Doom decides that after two years in the homeland he is ready to return.