All the couples are back for a vacation in viva Las Vegas. Where the old saying goes, "What happens in Vegas...stays in Vegas." One of the lucky couples from the last film is getting married, so each of them split off into gender groups. Each gender determined to have the time of their lives before the big wedding. However, things go haywire, as this may turn out to be one vacation they may not soon forget.

After a horrible blind date, two single parents agree to never see each other again. But as luck would have it, they somehow end up on the same vacation together in Africa. While the parents blend together, they're kids benefit from the burgeoning relationship. Hijinks and comedy will pursue in this romantic comedy featuring Adam Sandler and Drew Barrymore.