A USERS GUIDE TO IMMORTALITY

A Users Guide To Immortality

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Enquiry into the evolution of aging aims to explain why almost all living things weaken and die with age. There is not yet agreement in the scientific community on a single answer. The evolutionary origin of senescence remains a fundamental unsolved problem in biology.

Historically, aging was first likened to "wear and tear": living bodies get weaker just as with use a knife's edge becomes dulled or with exposure to air and moisture iron objects rust. But this idea was discredited in the 19th century when the second law of thermodynamics was formalized.

Entropy (disorder) must increase inevitably within a closed system , but living beings are not closed systems . It is a defining feature of life that it takes in free energy from the environment and unloads its entropy as waste.

Living systems can even build themselves up from seed, and routinely repair themselves. There is no thermodynamic necessity for senescence. In addition, generic damage or "wear and tear" theories could not explain why biologically similar organisms (e.g. mammals ) exhibited such dramatically different life spans.

Furthermore, this initial theory failed to explain why most organisms maintain themselves so efficiently until adulthood and then, after reproductive maturity, begin to succumb to age-related damage.

Aging has been slowed and healthy lifespan prolonged in many disparate animal models (C. elegans, Drosophila, Ames dwarf mice, etc.). Thus, assuming there are common fundamental mechanisms, it should also be possible to slow aging in humans.

Greater knowledge about aging should bring better management of the debilitating pathologies associated with aging, such as cancer, cardiovascular disease, type II diabetes, and Alzheimer's. Therapies targeted at the fundamental mechanisms of aging will be instrumental in counteracting these age-related pathologies.

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Therefore, this blog is a call to action for greater funding and research into both the underlying mechanisms of aging and methods for its postponement. Such research may yield dividends far greater than equal efforts to combat the age-related diseases themselves.

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